Detailed information of TA system TA268857

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2543645..2543916
• Replicon: chromosome
• Accession: NZ_CP116553
• Organism: Enterococcus faecalis strain K80-2b

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML81_RS11945
• Protein ID: WP_002375510.1
• Coordinates: 2543764..2543916 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2543645..2543831 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML81_RS11930 (2539612)	2539612..2542356	+	2745	WP_104807179.1	glycosyl hydrolase family 65 protein	-
PML81_RS11935 (2542371)	2542371..2543021	+	651	WP_002375514.1	beta-phosphoglucomutase	-
- (2543090)	2543090..2543222	+	133	NuclAT_12	-	-
- (2543269)	2543269..2543456	+	188	NuclAT_4	-	-
PML81_RS11940 (2543389)	2543389..2543493	-	105	WP_023894767.1	putative holin-like toxin	-
- (2543645)	2543645..2543790	+	146	NuclAT_11	-	-
- (2543645)	2543645..2543831	+	187	NuclAT_5	-	Antitoxin
PML81_RS11945 (2543764)	2543764..2543916	-	153	WP_002375510.1	type I toxin-antitoxin system toxin PepG1	Toxin
PML81_RS11950 (2544141)	2544141..2545112	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
PML81_RS11955 (2545287)	2545287..2545724	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
PML81_RS11960 (2545857)	2545857..2546411	-	555	WP_002354869.1	Maf family protein	-
PML81_RS11965 (2546436)	2546436..2548568	-	2133	WP_002375508.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (17-50)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5637.90 Da
• Isoelectric Point: 11.0942

>T268857 WP_002375510.1 NZ_CP116553:c2543916-2543764 [Enterococcus faecalis]
VVRMSALPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 187 bp

>AT268857 NZ_CP116553:2543645-2543831 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGAGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTTTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin