Detailed information of TA system TA268849

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2464711..2464972
• Replicon: chromosome
• Accession: NZ_CP116553
• Organism: Enterococcus faecalis strain K80-2b

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML81_RS11570
• Protein ID: WP_162780856.1
• Coordinates: 2464871..2464972 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2464711..2464917 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML81_RS11545 (2460366)	2460366..2461319	-	954	WP_002375576.1	siderophore ABC transporter substrate-binding protein	-
PML81_RS11550 (2461358)	2461358..2462113	-	756	WP_002375575.1	ATP-binding cassette domain-containing protein	-
PML81_RS11555 (2462110)	2462110..2463075	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
PML81_RS11560 (2463072)	2463072..2464019	-	948	WP_002375573.1	iron chelate uptake ABC transporter family permease subunit	-
PML81_RS11565 (2464203)	2464203..2464655	+	453	WP_002375572.1	YueI family protein	-
- (2464711)	2464711..2464917	+	207	NuclAT_7	-	Antitoxin
- (2464748)	2464748..2464934	+	187	NuclAT_9	-	-
PML81_RS11570 (2464871)	2464871..2464972	-	102	WP_162780856.1	putative holin-like toxin	Toxin
PML81_RS11575 (2465164)	2465164..2467434	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
PML81_RS11580 (2467605)	2467605..2468105	+	501	WP_002395960.1	cysteine hydrolase family protein	-
PML81_RS11585 (2468904)	2468904..2469800	+	897	WP_002368434.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3624.40 Da
• Isoelectric Point: 6.0656

>T268849 WP_162780856.1 NZ_CP116553:c2464972-2464871 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 207 bp

>AT268849 NZ_CP116553:2464711-2464917 [Enterococcus faecalis]
TTCCATTTATAATAGAATTGTGCTATTATGAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTATACCAGCG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGG
TTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin