268834

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 122863..123398 Replicon plasmid pK162-1-A
Accession NZ_CP116537
Organism Enterococcus faecium strain K162-1

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag PML70_RS13660 Protein ID WP_002314366.1
Coordinates 122863..123135 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag PML70_RS13665 Protein ID WP_002297422.1
Coordinates 123135..123398 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML70_RS13630 (PML70_13630) 118386..119515 + 1130 WP_119657924.1 IS3 family transposase -
PML70_RS13635 (PML70_13635) 119665..120228 - 564 WP_002316729.1 hypothetical protein -
PML70_RS13640 (PML70_13640) 120488..121036 - 549 WP_002292681.1 hypothetical protein -
PML70_RS13645 (PML70_13645) 121037..121894 - 858 WP_002292680.1 ParA family protein -
PML70_RS13650 (PML70_13650) 122180..122467 - 288 WP_130624911.1 type II toxin-antitoxin system RelE/ParE family toxin -
PML70_RS13655 (PML70_13655) 122457..122786 - 330 WP_002292678.1 AbrB family transcriptional regulator -
PML70_RS13660 (PML70_13660) 122863..123135 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
PML70_RS13665 (PML70_13665) 123135..123398 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PML70_RS13670 (PML70_13670) 123632..124540 + 909 Protein_132 IS982-like element ISEfm1 family transposase -
PML70_RS13675 (PML70_13675) 124543..125718 - 1176 WP_002336205.1 MFS transporter -
PML70_RS13680 (PML70_13680) 125721..127970 - 2250 WP_272016958.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - bopD 1..134360 134360


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T268834 WP_002314366.1 NZ_CP116537:c123135-122863 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT268834 WP_002297422.1 NZ_CP116537:c123398-123135 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References