Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 936825..937420 Replicon chromosome
Accession NZ_CP116496
Organism MAG: Rickettsia asembonensis isolate Perak

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PG979_RS05260 Protein ID WP_277360378.1
Coordinates 936825..937103 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PG979_RS05265 Protein ID WP_041077923.1
Coordinates 937118..937420 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG979_RS05230 (PG979_001068) 932351..932593 - 243 WP_277360376.1 GIY-YIG nuclease family protein -
PG979_RS05235 (PG979_001069) 932671..933273 - 603 WP_041077913.1 peroxiredoxin -
PG979_RS05240 (PG979_001070) 933355..934290 - 936 WP_041077915.1 stomatin-like protein -
PG979_RS05245 (PG979_001071) 934353..934595 - 243 WP_041077917.1 hypothetical protein -
PG979_RS05250 (PG979_001073) 934662..936229 - 1568 Protein_992 phosphoethanolamine transferase -
PG979_RS05255 (PG979_001074) 936265..936729 + 465 WP_277360377.1 Holliday junction resolvase RuvX -
PG979_RS05260 (PG979_001075) 936825..937103 + 279 WP_277360378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PG979_RS05265 (PG979_001076) 937118..937420 + 303 WP_041077923.1 HigA family addiction module antitoxin Antitoxin
PG979_RS05270 937500..938353 + 854 Protein_996 SDR family oxidoreductase -
PG979_RS05275 938393..938521 - 129 WP_277361026.1 palindromic element RPE4 domain-containing protein -
PG979_RS05280 (PG979_001078) 938552..939577 + 1026 WP_041077927.1 UDP-glucose 4-epimerase -
PG979_RS05285 (PG979_001079) 939570..940703 + 1134 WP_277360379.1 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
PG979_RS05290 940663..941388 + 726 Protein_1000 hypothetical protein -
PG979_RS05295 (PG979_001081) 941404..941886 + 483 Protein_1001 class I SAM-dependent methyltransferase -
PG979_RS05300 (PG979_001082) 942093..942305 + 213 WP_277360380.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(24-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 11135.90 Da        Isoelectric Point: 9.6841

>T268814 WP_277360378.1 NZ_CP116496:936825-937103 [Rickettsia asembonensis]
MIISFKCKHTEKLHNRELVKRFEVFAEIARKKLFMLHTTVNLEDLRVPPSNRLESLKGDRKHQYSIHINSQWRICFIWHD
GNVHNVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11660.45 Da        Isoelectric Point: 8.5757

>AT268814 WP_041077923.1 NZ_CP116496:937118-937420 [Rickettsia asembonensis]
MTNKLPPISPGQILLEEFMEPMGISQSKLARDIDVPVTRINNIIKHHRSITADTALRLGKYFNVNPRWWMNMQNQYDLEL
AEDEGWKVKESRIRTFSMAS

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References