Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1653254..1653893 Replicon chromosome
Accession NZ_CP116490
Organism Haemophilus influenzae strain 93P10H1

Toxin (Protein)


Gene name higB Uniprot ID Q4QJX7
Locus tag BV187_RS08130 Protein ID WP_005650215.1
Coordinates 1653588..1653893 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BV187_RS08125 Protein ID WP_005650217.1
Coordinates 1653254..1653577 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV187_RS08105 (BV187_1641) 1648873..1649046 - 174 WP_011272700.1 DUF5363 domain-containing protein -
BV187_RS08110 (BV187_1642) 1649043..1651013 - 1971 WP_011961904.1 GNAT family N-acetyltransferase -
BV187_RS08115 (BV187_1643) 1651018..1651359 - 342 WP_005652996.1 SirB2 family protein -
BV187_RS08120 (BV187_1644) 1651421..1653091 - 1671 WP_005650218.1 energy-dependent translational throttle protein EttA -
BV187_RS08125 (BV187_1645) 1653254..1653577 - 324 WP_005650217.1 HigA family addiction module antitoxin Antitoxin
BV187_RS08130 (BV187_1646) 1653588..1653893 - 306 WP_005650215.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BV187_RS08135 (BV187_1647) 1654218..1654838 + 621 WP_005666732.1 zinc transporter binding subunit ZevA -
BV187_RS08140 (BV187_1648) 1654841..1655809 + 969 WP_005666730.1 zinc transporter permease subunit ZevB -
BV187_RS08150 (BV187_1650) 1656424..1658463 + 2040 WP_005687320.1 excinuclease ABC subunit UvrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-99)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12301.93 Da        Isoelectric Point: 9.0853

>T268787 WP_005650215.1 NZ_CP116490:c1653893-1653588 [Haemophilus influenzae]
MFNLKREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12347.17 Da        Isoelectric Point: 6.8804

>AT268787 WP_005650217.1 NZ_CP116490:c1653577-1653254 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806EC70

Antitoxin

Source ID Structure

References