268782

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 729312..730660 Replicon chromosome
Accession NZ_CP116490
Organism Haemophilus influenzae strain 93P10H1

Toxin (Protein)


Gene name HipT Uniprot ID A0A5C6GXP8
Locus tag BV187_RS03615 Protein ID WP_012054635.1
Coordinates 729312..730343 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2R3FM14
Locus tag BV187_RS03620 Protein ID WP_005687922.1
Coordinates 730340..730660 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV187_RS03600 725152..725310 - 159 WP_272524520.1 PT domain-containing protein -
BV187_RS03605 (BV187_0733) 725832..727577 + 1746 WP_012054637.1 ABC transporter ATP-binding protein/permease -
BV187_RS03610 (BV187_0734) 727570..729228 + 1659 WP_012054636.1 thiol reductant ABC exporter subunit CydC -
BV187_RS03615 (BV187_0735) 729312..730343 - 1032 WP_012054635.1 HipA domain-containing protein Toxin
BV187_RS03620 (BV187_0736) 730340..730660 - 321 WP_005687922.1 HipA N-terminal domain-containing protein Antitoxin
BV187_RS03625 (BV187_0737) 730648..730956 - 309 WP_005661200.1 helix-turn-helix transcriptional regulator -
BV187_RS03630 (BV187_0738) 731156..732157 - 1002 WP_005687920.1 class II fructose-bisphosphatase -
BV187_RS03635 (BV187_0739) 732319..732537 + 219 WP_005650820.1 cell division protein ZapB -
BV187_RS03640 (BV187_0740) 732631..733071 + 441 WP_005687918.1 FMN-binding protein MioC -
BV187_RS03645 (BV187_0741) 733068..733502 + 435 WP_005687917.1 D-aminoacyl-tRNA deacylase -
BV187_RS03650 (BV187_0742) 733804..734280 - 477 WP_005687916.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
BV187_RS03655 (BV187_0743) 734277..734954 - 678 WP_012054634.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
BV187_RS03660 (BV187_0744) 734954..735232 - 279 WP_005665661.1 cell division protein FtsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39830.34 Da        Isoelectric Point: 6.5052

>T268782 WP_012054635.1 NZ_CP116490:c730343-729312 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSDYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDGHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Download         Length: 1032 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12407.09 Da        Isoelectric Point: 5.9670

>AT268782 WP_005687922.1 NZ_CP116490:c730660-730340 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C6GXP8

Antitoxin

Source ID Structure
AlphaFold DB A0A2R3FM14

References