Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1435494..1436133 Replicon chromosome
Accession NZ_CP116489
Organism Haemophilus influenzae strain 93P28H1

Toxin (Protein)


Gene name higB Uniprot ID Q4QJX7
Locus tag BV189_RS07045 Protein ID WP_005650215.1
Coordinates 1435494..1435799 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BV189_RS07050 Protein ID WP_005650217.1
Coordinates 1435810..1436133 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV189_RS07025 (BV189_1421) 1430924..1432963 - 2040 WP_005687320.1 excinuclease ABC subunit UvrB -
BV189_RS07035 (BV189_1423) 1433578..1434546 - 969 WP_005666730.1 zinc transporter permease subunit ZevB -
BV189_RS07040 (BV189_1424) 1434549..1435169 - 621 WP_005666732.1 zinc transporter binding subunit ZevA -
BV189_RS07045 (BV189_1425) 1435494..1435799 + 306 WP_005650215.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BV189_RS07050 (BV189_1426) 1435810..1436133 + 324 WP_005650217.1 HigA family addiction module antitoxin Antitoxin
BV189_RS07055 (BV189_1427) 1436296..1437966 + 1671 WP_005650218.1 energy-dependent translational throttle protein EttA -
BV189_RS07060 (BV189_1428) 1438028..1438369 + 342 WP_005652996.1 SirB2 family protein -
BV189_RS07065 (BV189_1429) 1438374..1440344 + 1971 WP_011961904.1 GNAT family N-acetyltransferase -
BV189_RS07070 (BV189_1430) 1440341..1440514 + 174 WP_011272700.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-99)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12301.93 Da        Isoelectric Point: 9.0853

>T268778 WP_005650215.1 NZ_CP116489:1435494-1435799 [Haemophilus influenzae]
MFNLKREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12347.17 Da        Isoelectric Point: 6.8804

>AT268778 WP_005650217.1 NZ_CP116489:1435810-1436133 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806EC70

Antitoxin

Source ID Structure

References