268773

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 729327..730675 Replicon chromosome
Accession NZ_CP116489
Organism Haemophilus influenzae strain 93P28H1

Toxin (Protein)


Gene name HipT Uniprot ID A0A5C6GXP8
Locus tag BV189_RS03620 Protein ID WP_012054635.1
Coordinates 729327..730358 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2R3FM14
Locus tag BV189_RS03625 Protein ID WP_005687922.1
Coordinates 730355..730675 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV189_RS03605 725167..725325 - 159 WP_272524520.1 PT domain-containing protein -
BV189_RS03610 (BV189_0736) 725847..727592 + 1746 WP_012054637.1 ABC transporter ATP-binding protein/permease -
BV189_RS03615 (BV189_0737) 727585..729243 + 1659 WP_012054636.1 thiol reductant ABC exporter subunit CydC -
BV189_RS03620 (BV189_0738) 729327..730358 - 1032 WP_012054635.1 HipA domain-containing protein Toxin
BV189_RS03625 (BV189_0739) 730355..730675 - 321 WP_005687922.1 HipA N-terminal domain-containing protein Antitoxin
BV189_RS03630 (BV189_0740) 730663..730971 - 309 WP_005661200.1 helix-turn-helix transcriptional regulator -
BV189_RS03635 (BV189_0741) 731171..732172 - 1002 WP_005687920.1 class II fructose-bisphosphatase -
BV189_RS03640 (BV189_0742) 732334..732552 + 219 WP_005650820.1 cell division protein ZapB -
BV189_RS03645 (BV189_0743) 732646..733086 + 441 WP_005687918.1 FMN-binding protein MioC -
BV189_RS03650 (BV189_0744) 733083..733517 + 435 WP_005687917.1 D-aminoacyl-tRNA deacylase -
BV189_RS03655 (BV189_0745) 733819..734295 - 477 WP_005687916.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
BV189_RS03660 (BV189_0746) 734292..734969 - 678 WP_012054634.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
BV189_RS03665 (BV189_0747) 734969..735247 - 279 WP_005665661.1 cell division protein FtsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39830.34 Da        Isoelectric Point: 6.5052

>T268773 WP_012054635.1 NZ_CP116489:c730358-729327 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSDYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDGHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Download         Length: 1032 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12407.09 Da        Isoelectric Point: 5.9670

>AT268773 WP_005687922.1 NZ_CP116489:c730675-730355 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C6GXP8

Antitoxin

Source ID Structure
AlphaFold DB A0A2R3FM14

References