Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 378371..379095 Replicon chromosome
Accession NZ_CP116477
Organism Pectobacterium sp. A5351

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag O1Q74_RS01775 Protein ID WP_271875839.1
Coordinates 378371..378682 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag O1Q74_RS01780 Protein ID WP_271875840.1
Coordinates 378679..379095 (+) Length 139 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1Q74_RS01760 (O1Q74_01760) 374531..376066 - 1536 WP_271875836.1 carbohydrate porin -
O1Q74_RS01765 (O1Q74_01765) 376255..377190 - 936 WP_271875837.1 aminoimidazole riboside kinase -
O1Q74_RS01770 (O1Q74_01770) 377661..378212 + 552 WP_271875838.1 polymer-forming cytoskeletal protein -
O1Q74_RS01775 (O1Q74_01775) 378371..378682 + 312 WP_271875839.1 type II toxin-antitoxin system HigB family toxin Toxin
O1Q74_RS01780 (O1Q74_01780) 378679..379095 + 417 WP_271875840.1 helix-turn-helix domain-containing protein Antitoxin
O1Q74_RS01785 (O1Q74_01785) 379443..379889 + 447 WP_271875841.1 helix-turn-helix domain-containing protein -
O1Q74_RS01790 (O1Q74_01790) 379899..380360 + 462 WP_271875842.1 YhbP family protein -
O1Q74_RS01795 (O1Q74_01795) 380454..381107 + 654 WP_271875843.1 hypothetical protein -
O1Q74_RS01800 (O1Q74_01800) 381119..381583 - 465 WP_271875844.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
O1Q74_RS01805 (O1Q74_01805) 381665..383803 - 2139 WP_271875845.1 anaerobic ribonucleoside-triphosphate reductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12439.28 Da        Isoelectric Point: 9.6392

>T268716 WP_271875839.1 NZ_CP116477:378371-378682 [Pectobacterium sp. A5351]
MHVISRAPFDTATTQFPNQAAALADLYRVIKREMYATPDDMKKRFPSLDRMKYREKWWVIDIGGGHLRMMFFADFERGEI
FIKHITSHAEYDRLTEYYRRNKE

Download         Length: 312 bp


Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15412.67 Da        Isoelectric Point: 4.5581

>AT268716 WP_271875840.1 NZ_CP116477:378679-379095 [Pectobacterium sp. A5351]
MMYADAIKAANNLMSIVPFLGGSTSRKDYEDALKLTEYLIESEPDSPLIDMLTAKIDKYEDDASEFAAFNERVKALPAGI
ALLRVLMDQHQLTQSDFEAEIGKKSLVSRILNGERTLTLDHMRALAKRFDIPVSAFVD

Download         Length: 417 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References