Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 638018..638850 Replicon chromosome
Accession NZ_CP116458
Organism Acidithiobacillus ferriphilus strain YL25

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag PJU76_RS03165 Protein ID WP_271780451.1
Coordinates 638344..638850 (+) Length 169 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag PJU76_RS03160 Protein ID WP_271781035.1
Coordinates 638018..638347 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJU76_RS03120 (PJU76_03120) 633533..634003 + 471 WP_271781034.1 N-6 DNA methylase -
PJU76_RS03125 (PJU76_03125) 634046..634327 + 282 WP_271780445.1 BrnT family toxin -
PJU76_RS03130 (PJU76_03130) 634278..634610 + 333 WP_271780446.1 BrnA antitoxin family protein -
PJU76_RS03135 (PJU76_03135) 634654..635499 - 846 WP_271780447.1 thioredoxin fold domain-containing protein -
PJU76_RS03140 (PJU76_03140) 636223..636537 - 315 WP_271780448.1 DUF86 domain-containing protein -
PJU76_RS03145 (PJU76_03145) 636534..636824 - 291 WP_271780449.1 nucleotidyltransferase domain-containing protein -
PJU76_RS03150 (PJU76_03150) 637077..637307 + 231 WP_271780450.1 hypothetical protein -
PJU76_RS03155 (PJU76_03155) 637409..637846 + 438 Protein_622 IS3 family transposase -
PJU76_RS03160 (PJU76_03160) 638018..638347 + 330 WP_271781035.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
PJU76_RS03165 (PJU76_03165) 638344..638850 + 507 WP_271780451.1 type II toxin-antitoxin system YhaV family toxin Toxin
PJU76_RS03170 (PJU76_03170) 640572..642734 - 2163 WP_271780452.1 TniQ family protein -
PJU76_RS03175 (PJU76_03175) 642734..643720 - 987 WP_229066188.1 TniB family NTP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 629929..672774 42845


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(16-152)

Antitoxin

PrlF antitoxin

(8-107)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 19620.45 Da        Isoelectric Point: 10.2710

>T268708 WP_271780451.1 NZ_CP116458:638344-638850 [Acidithiobacillus ferriphilus]
MNLGKPDPLVIHGWTVFVHPLFLAQLEALARQVGAFKQKDPVGYVKKNASKRLAAITKLAFDVIPQNPARPEYRQGNTLG
DEYKHWFRARFFQQYRLFFRYHASSKVIVFVWVNDEDTKRAYESSDDAYRVFRKMLESGHPPDDWKHLLAEARAERQRLQ
PFTSAITP

Download         Length: 507 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12095.66 Da        Isoelectric Point: 4.4829

>AT268708 WP_271781035.1 NZ_CP116458:638018-638347 [Acidithiobacillus ferriphilus]
MPTTLEVESTLTDRYQTTVPETVRRALKLGKRDKIHYTIRLSGEVVLTRAEVGEDDDPVLGQFLDFLAHDIASHPERLQV
VDVGLVRRLQSLVGGIEVNLDAALSADDE

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References