268696

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4622406..4623008 Replicon chromosome
Accession NZ_CP116411
Organism Escherichia coli strain HH45

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag PL330_RS21950 Protein ID WP_000897305.1
Coordinates 4622697..4623008 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PL330_RS21945 Protein ID WP_000356397.1
Coordinates 4622406..4622696 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL330_RS21920 (4618332) 4618332..4619234 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
PL330_RS21925 (4619231) 4619231..4619866 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PL330_RS21930 (4619863) 4619863..4620792 + 930 WP_000027706.1 formate dehydrogenase accessory protein FdhE -
PL330_RS21935 (4621122) 4621122..4621364 - 243 WP_001087409.1 protein YiiF -
PL330_RS21940 (4621583) 4621583..4621801 - 219 WP_001295676.1 CopG family transcriptional regulator -
PL330_RS21945 (4622406) 4622406..4622696 - 291 WP_000356397.1 NadS family protein Antitoxin
PL330_RS21950 (4622697) 4622697..4623008 - 312 WP_000897305.1 hypothetical protein Toxin
PL330_RS21955 (4623237) 4623237..4624145 + 909 WP_001162704.1 alpha/beta hydrolase -
PL330_RS21960 (4624209) 4624209..4625150 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PL330_RS21965 (4625195) 4625195..4625632 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PL330_RS21970 (4625629) 4625629..4626501 - 873 WP_000920762.1 virulence factor BrkB family protein -
PL330_RS21975 (4626495) 4626495..4627094 - 600 WP_001295269.1 glucose-1-phosphatase -
PL330_RS21980 (4627193) 4627193..4627978 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T268696 WP_000897305.1 NZ_CP116411:c4623008-4622697 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT268696 WP_000356397.1 NZ_CP116411:c4622696-4622406 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References