Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3999006..3999264 Replicon chromosome
Accession NZ_CP116411
Organism Escherichia coli strain HH45

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag PL330_RS19075 Protein ID WP_000809168.1
Coordinates 3999112..3999264 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3999006..3999063 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL330_RS19050 3994312..3995253 - 942 WP_000767329.1 bifunctional riboflavin kinase/FAD synthetase -
PL330_RS19055 3995261..3995479 - 219 WP_001295417.1 DUF2575 family protein -
PL330_RS19060 3995582..3995845 + 264 WP_001274021.1 30S ribosomal protein S20 -
PL330_RS19065 3996389..3997294 - 906 WP_271710796.1 transcriptional activator NhaR -
PL330_RS19070 3997360..3998526 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 3999006..3999063 - 58 - - Antitoxin
PL330_RS19075 3999112..3999264 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
PL330_RS19080 3999368..4000498 - 1131 WP_001118464.1 molecular chaperone DnaJ -
PL330_RS19085 4000587..4002503 - 1917 WP_000516135.1 molecular chaperone DnaK -
PL330_RS19090 4002880..4003284 + 405 WP_000843568.1 DUF2541 family protein -
PL330_RS19095 4003310..4004023 + 714 WP_001102379.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T268694 WP_000809168.1 NZ_CP116411:3999112-3999264 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT268694 NZ_CP116411:c3999063-3999006 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References