268693

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3744326..3744867 Replicon chromosome
Accession NZ_CP116411
Organism Escherichia coli strain HH45

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag PL330_RS17915 Protein ID WP_000615976.1
Coordinates 3744589..3744867 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag PL330_RS17910 Protein ID WP_000729704.1
Coordinates 3744326..3744586 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL330_RS17890 (3740003) 3740003..3740788 - 786 WP_000207574.1 putative lateral flagellar export/assembly protein LafU -
PL330_RS17895 (3740760) 3740760..3742472 + 1713 Protein_3505 flagellar biosynthesis protein FlhA -
PL330_RS17900 (3742695) 3742695..3743192 - 498 WP_000006241.1 REP-associated tyrosine transposase RayT -
PL330_RS17905 (3743367) 3743367..3744140 - 774 WP_000543899.1 C40 family peptidase -
PL330_RS17910 (3744326) 3744326..3744586 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
PL330_RS17915 (3744589) 3744589..3744867 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
PL330_RS17920 (3745023) 3745023..3745763 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
PL330_RS17925 (3745734) 3745734..3746501 - 768 WP_000333380.1 class II glutamine amidotransferase -
PL330_RS17930 (3746707) 3746707..3747285 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T268693 WP_000615976.1 NZ_CP116411:3744589-3744867 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT268693 WP_000729704.1 NZ_CP116411:3744326-3744586 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6Z6

References