Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 567598..568397 Replicon chromosome
Accession NZ_CP116411
Organism Escherichia coli strain HH45

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag PL330_RS02765 Protein ID WP_000347267.1
Coordinates 567598..568062 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PL330_RS02770 Protein ID WP_001307405.1
Coordinates 568062..568397 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL330_RS02735 (562599) 562599..563033 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PL330_RS02740 (563051) 563051..563929 - 879 WP_001380079.1 PTS N-acetylgalactosamine transporter subunit IID -
PL330_RS02745 (563919) 563919..564698 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PL330_RS02750 (564709) 564709..565182 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PL330_RS02755 (565205) 565205..566485 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
PL330_RS02760 (566734) 566734..567543 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PL330_RS02765 (567598) 567598..568062 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PL330_RS02770 (568062) 568062..568397 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PL330_RS02775 (568546) 568546..570117 - 1572 WP_001273741.1 galactarate dehydratase -
PL330_RS02780 (570492) 570492..571826 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PL330_RS02785 (571842) 571842..572612 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T268682 WP_000347267.1 NZ_CP116411:c568062-567598 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT268682 WP_001307405.1 NZ_CP116411:c568397-568062 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References