Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 93255..93857 Replicon chromosome
Accession NZ_CP116409
Organism Escherichia coli strain HH97

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag PL329_RS00415 Protein ID WP_000897302.1
Coordinates 93546..93857 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PL329_RS00410 Protein ID WP_000356397.1
Coordinates 93255..93545 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL329_RS00385 (89202) 89202..90104 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
PL329_RS00390 (90101) 90101..90736 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PL329_RS00395 (90733) 90733..91662 + 930 WP_000027705.1 formate dehydrogenase accessory protein FdhE -
PL329_RS00400 (91992) 91992..92234 - 243 WP_001086388.1 protein YiiF -
PL329_RS00405 (92452) 92452..92670 - 219 WP_001295676.1 CopG family transcriptional regulator -
PL329_RS00410 (93255) 93255..93545 - 291 WP_000356397.1 NadS family protein Antitoxin
PL329_RS00415 (93546) 93546..93857 - 312 WP_000897302.1 hypothetical protein Toxin
PL329_RS00420 (94086) 94086..94994 + 909 WP_271711088.1 alpha/beta hydrolase -
PL329_RS00425 (95058) 95058..95999 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PL329_RS00430 (96044) 96044..96481 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PL329_RS00435 (96478) 96478..97350 - 873 WP_000920762.1 virulence factor BrkB family protein -
PL329_RS00440 (97344) 97344..97943 - 600 WP_001308174.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T268663 WP_000897302.1 NZ_CP116409:c93857-93546 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT268663 WP_000356397.1 NZ_CP116409:c93545-93255 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References