Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 773626..774319 Replicon chromosome
Accession NZ_CP116405
Organism Escherichia coli strain HH107

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PL328_RS03715 Protein ID WP_000415584.1
Coordinates 773626..773922 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PL328_RS03720 Protein ID WP_000650107.1
Coordinates 773924..774319 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL328_RS03685 (768646) 768646..768978 + 333 WP_000914691.1 DUF2645 family protein -
PL328_RS03690 (769024) 769024..770373 - 1350 WP_000673354.1 quorum sensing histidine kinase QseC -
PL328_RS03695 (770370) 770370..771029 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
PL328_RS03700 (771181) 771181..771573 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PL328_RS03710 (772966) 772966..773421 + 456 WP_244557681.1 GyrI-like domain-containing protein -
PL328_RS03715 (773626) 773626..773922 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PL328_RS03720 (773924) 773924..774319 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PL328_RS03725 (774452) 774452..776059 + 1608 WP_096926439.1 ABC transporter substrate-binding protein -
PL328_RS03730 (776197) 776197..778455 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T268644 WP_000415584.1 NZ_CP116405:773626-773922 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT268644 WP_000650107.1 NZ_CP116405:773924-774319 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References