Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 730544..731063 Replicon chromosome
Accession NZ_CP116393
Organism Streptococcus suis strain SS/UPM/MY/F001

Toxin (Protein)


Gene name yoeB Uniprot ID A0A116LIJ2
Locus tag PFZ59_RS03830 Protein ID WP_044773375.1
Coordinates 730806..731063 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0M9FLP3
Locus tag PFZ59_RS03825 Protein ID WP_029693536.1
Coordinates 730544..730804 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFZ59_RS03800 (PFZ59_03800) 726348..727301 + 954 WP_277697289.1 IS30 family transposase -
PFZ59_RS03805 (PFZ59_03805) 727470..727607 + 138 WP_002939016.1 50S ribosomal protein L34 -
PFZ59_RS03810 (PFZ59_03810) 727714..728496 + 783 WP_105184278.1 TatD family hydrolase -
PFZ59_RS03815 (PFZ59_03815) 728480..729049 + 570 WP_277697513.1 ribonuclease M5 -
PFZ59_RS03820 (PFZ59_03820) 729414..729869 + 456 WP_277697778.1 8-oxo-dGTP diphosphatase -
PFZ59_RS03825 (PFZ59_03825) 730544..730804 + 261 WP_029693536.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PFZ59_RS03830 (PFZ59_03830) 730806..731063 + 258 WP_044773375.1 Txe/YoeB family addiction module toxin Toxin
PFZ59_RS03835 (PFZ59_03835) 731178..732053 + 876 WP_277697514.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
PFZ59_RS03840 (PFZ59_03840) 732050..732835 + 786 WP_277697515.1 ElyC/SanA/YdcF family protein -
PFZ59_RS03845 (PFZ59_03845) 732999..734717 + 1719 WP_277697516.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 726348..727301 953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10279.70 Da        Isoelectric Point: 6.7242

>T268631 WP_044773375.1 NZ_CP116393:730806-731063 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADQLYILSL
KDHYG

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9950.29 Da        Isoelectric Point: 5.1255

>AT268631 WP_029693536.1 NZ_CP116393:730544-730804 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAQVKAGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A116LIJ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0M9FLP3

References