Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1765473..1766063 Replicon chromosome
Accession NZ_CP116392
Organism Brevibacterium sp. BDJS002

Toxin (Protein)


Gene name graT Uniprot ID A0A2A3ZLA3
Locus tag PGC08_RS08170 Protein ID WP_009883719.1
Coordinates 1765473..1765754 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PGC08_RS08175 Protein ID WP_009883720.1
Coordinates 1765764..1766063 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGC08_RS08145 (PGC08_08145) 1760650..1761735 + 1086 WP_009883714.1 redox-regulated ATPase YchF -
PGC08_RS08150 (PGC08_08150) 1761741..1762427 - 687 WP_009883715.1 haloacid dehalogenase type II -
PGC08_RS08155 (PGC08_08155) 1762607..1763197 - 591 WP_009883716.1 GNAT family N-acetyltransferase -
PGC08_RS08160 (PGC08_08160) 1763194..1763799 - 606 WP_009883717.1 TetR/AcrR family transcriptional regulator -
PGC08_RS08165 (PGC08_08165) 1763971..1764336 + 366 WP_271710054.1 zinc ribbon domain-containing protein YjdM -
PGC08_RS08170 (PGC08_08170) 1765473..1765754 + 282 WP_009883719.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PGC08_RS08175 (PGC08_08175) 1765764..1766063 + 300 WP_009883720.1 HigA family addiction module antitoxin Antitoxin
PGC08_RS08180 (PGC08_08180) 1766097..1767287 + 1191 WP_271709927.1 PD-(D/E)XK nuclease family protein -
PGC08_RS08185 (PGC08_08185) 1767364..1768404 - 1041 WP_271709928.1 methionine synthase -
PGC08_RS08190 (PGC08_08190) 1768422..1769414 - 993 WP_069599929.1 DUF1852 family protein -
PGC08_RS08195 (PGC08_08195) 1769540..1770481 + 942 WP_029417202.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10928.30 Da        Isoelectric Point: 10.7346

>T268629 WP_009883719.1 NZ_CP116392:1765473-1765754 [Brevibacterium sp. BDJS002]
VIRSFADRDTERVWRREPARRLDPRIHKTANRKLHQLDAAVSLDSMRVPPGNRLESLRGDRAGQHSIRINDQWRICFRWT
GAGAEEVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11132.84 Da        Isoelectric Point: 5.7011

>AT268629 WP_009883720.1 NZ_CP116392:1765764-1766063 [Brevibacterium sp. BDJS002]
MSEKLYPPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRAITADTALRLGRYFGVEPQFWLNLQSRYDLE
LAEERVSDQVAAITPLKVA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A3ZLA3

Antitoxin

Source ID Structure

References