268623

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 578975..579620 Replicon chromosome
Accession NZ_CP116384
Organism Vibrio sp. SCSIO 43137

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PK654_RS18475 Protein ID WP_271700542.1
Coordinates 578975..579334 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PK654_RS18480 Protein ID WP_271700543.1
Coordinates 579315..579620 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PK654_RS18450 (PK654_18450) 574203..574769 - 567 WP_271700537.1 class GN sortase -
PK654_RS18455 (PK654_18455) 574751..576718 - 1968 WP_271700538.1 marine proteobacterial sortase target protein -
PK654_RS18460 (PK654_18460) 576816..577298 - 483 WP_271700539.1 hypothetical protein -
PK654_RS18465 (PK654_18465) 577378..577629 - 252 WP_271700540.1 hypothetical protein -
PK654_RS18470 (PK654_18470) 577822..578541 - 720 WP_271700541.1 SDR family NAD(P)-dependent oxidoreductase -
PK654_RS18475 (PK654_18475) 578975..579334 + 360 WP_271700542.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PK654_RS18480 (PK654_18480) 579315..579620 + 306 WP_271700543.1 XRE family transcriptional regulator Antitoxin
PK654_RS18485 (PK654_18485) 579924..581393 + 1470 WP_271700720.1 cobyric acid synthase -
PK654_RS18490 (PK654_18490) 581390..582703 + 1314 WP_271700544.1 cobyrinate a,c-diamide synthase -
PK654_RS18495 (PK654_18495) 582700..583302 + 603 WP_271700545.1 histidine phosphatase family protein -
PK654_RS18500 (PK654_18500) 583275..583883 + 609 WP_271700546.1 histidine phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 575931..791825 215894


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13800.20 Da        Isoelectric Point: 10.9550

>T268623 WP_271700542.1 NZ_CP116384:578975-579334 [Vibrio sp. SCSIO 43137]
MWNVVLRPVFIDWFRALESKDKINVRASIELLKQVGPNLSRPHADTLKGSRLRKLKELRVQSSGKPIRVLFAFDPERQCV
VLCGGNKTADKKFYKKIIPLAEREFSKHLKERNNEKPTS

Download         Length: 360 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11244.99 Da        Isoelectric Point: 4.9314

>AT268623 WP_271700543.1 NZ_CP116384:579315-579620 [Vibrio sp. SCSIO 43137]
MKSQPLNVLDELMSEEELEQAKVKAESMLFELNLAELRHLAQKSQTEVAEIMGVKQPTVANLEKNGKDVKLLSLKRYVEA
LGGKLTLNIELSDGSHRGLDI

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References