268617

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 6608927..6609631 Replicon chromosome
Accession NZ_CP116355
Organism Streptomyces xanthophaeus strain KPP03845

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag KPP03845_RS30230 Protein ID WP_272261605.1
Coordinates 6609272..6609631 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KPP03845_RS30225 Protein ID WP_272261604.1
Coordinates 6608927..6609238 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPP03845_RS30200 (KPP03845_106032) 6604149..6604322 - 174 WP_272261599.1 hypothetical protein -
KPP03845_RS30205 (KPP03845_106033) 6604396..6604566 - 171 WP_272261600.1 hypothetical protein -
KPP03845_RS30210 (KPP03845_106034) 6605328..6606458 + 1131 WP_272261602.1 helix-turn-helix transcriptional regulator -
KPP03845_RS30215 (KPP03845_106035) 6606442..6607218 - 777 WP_272263610.1 NUDIX domain-containing protein -
KPP03845_RS30220 6607925..6608476 - 552 WP_272261603.1 hypothetical protein -
KPP03845_RS30225 6608927..6609238 - 312 WP_272261604.1 XRE family transcriptional regulator Antitoxin
KPP03845_RS30230 6609272..6609631 - 360 WP_272261605.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KPP03845_RS30235 (KPP03845_106036) 6609808..6610917 + 1110 WP_272261606.1 ATP-binding protein -
KPP03845_RS30240 (KPP03845_106037) 6611149..6612366 + 1218 WP_272261607.1 restriction endonuclease -
KPP03845_RS30245 (KPP03845_106038) 6612434..6613408 + 975 WP_272261608.1 NaeI family type II restriction endonuclease -
KPP03845_RS30250 (KPP03845_106039) 6613863..6614288 + 426 WP_272261609.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13139.98 Da        Isoelectric Point: 6.4858

>T268617 WP_272261605.1 NZ_CP116355:c6609631-6609272 [Streptomyces xanthophaeus]
VSWSVVVVDEVRDWLHLLRREDRETLLAISAAIDVLEAQGPGLGRPLVDTVHGSQLSHLKELRPGSSGSSEVRILFAFDP
ARQAVLLVAGDKSGNWKGWYESAIPVAEERYRVHVAKMA

Download         Length: 360 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11398.03 Da        Isoelectric Point: 5.8945

>AT268617 WP_272261604.1 NZ_CP116355:c6609238-6608927 [Streptomyces xanthophaeus]
MSTNWRDLRGELLGPEDEPEVDALRGQMLAEVRAHRLAEARKRRQMTQKSMASLMGISQSRVSAIERGDLNRSELSTLVA
YVSALGGKLEIVADFGDEKIILG

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References