Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4209..4711 Replicon plasmid p2_120063
Accession NZ_CP116252
Organism Enterobacter roggenkampii strain 120063

Toxin (Protein)


Gene name yoeB Uniprot ID V0ABG6
Locus tag KK030_RS26130 Protein ID WP_023157375.1
Coordinates 4209..4463 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KK030_RS26135 Protein ID WP_024176566.1
Coordinates 4460..4711 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK030_RS26125 2179..4023 + 1845 WP_271800764.1 autotransporter outer membrane beta-barrel domain-containing protein -
KK030_RS26130 (KK030_26075) 4209..4463 - 255 WP_023157375.1 Txe/YoeB family addiction module toxin Toxin
KK030_RS26135 (KK030_26080) 4460..4711 - 252 WP_024176566.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
KK030_RS26140 (KK030_26085) 4961..5170 + 210 WP_214575080.1 hypothetical protein -
KK030_RS26145 (KK030_26090) 5143..5358 - 216 WP_072048928.1 MbeD family mobilization/exclusion protein -
KK030_RS26150 (KK030_26095) 5365..5862 - 498 WP_024176569.1 MbeB family mobilization protein -
KK030_RS26155 (KK030_26100) 5897..6331 - 435 Protein_7 relaxase/mobilization nuclease domain-containing protein -
KK030_RS26160 (KK030_26105) 6540..6863 - 324 WP_214575081.1 MobC family plasmid mobilization relaxosome protein -
KK030_RS26165 (KK030_26110) 7072..7275 - 204 WP_077695987.1 hypothetical protein -
KK030_RS26170 (KK030_26115) 7505..7651 + 147 WP_050863271.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..8252 8252
- flank IS/Tn - - 544..822 278
- flank IS/Tn - - 7927..8157 230


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9912.27 Da        Isoelectric Point: 8.8562

>T268565 WP_023157375.1 NZ_CP116252:c4463-4209 [Enterobacter roggenkampii]
VKLTWSAEAWEDYLYWQETDKKTVRKINELIKDASRTPFEGKGKPEPLKHNLAGFWSRRITAEHRIVYAVSDDALLIASC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9423.64 Da        Isoelectric Point: 4.6119

>AT268565 WP_024176566.1 NZ_CP116252:c4711-4460 [Enterobacter roggenkampii]
MRAVSYSEARQNLSTTMLQTVEDRAPVLITRQNGESCVLMSLEEYNSLEETAYLLRSPKNARRLMDSIESLKSGNGVERE
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0ABG6

Antitoxin

Source ID Structure

References