Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 45126..45790 Replicon chromosome
Accession NZ_CP116249
Organism Enterobacter roggenkampii strain 120063

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KK030_RS00225 Protein ID WP_214573812.1
Coordinates 45422..45790 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KK030_RS00220 Protein ID WP_214573810.1
Coordinates 45126..45425 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK030_RS00190 (KK030_00190) 40534..41493 - 960 WP_008500118.1 DUF523 and DUF1722 domain-containing protein -
KK030_RS00195 (KK030_00195) 41596..42006 - 411 WP_008500117.1 hydroxyisourate hydrolase -
KK030_RS00200 (KK030_00200) 42106..42831 - 726 WP_008500116.1 MerR family transcriptional regulator -
KK030_RS00205 (KK030_00205) 42949..43473 + 525 WP_008500115.1 lipocalin family protein -
KK030_RS00210 (KK030_00210) 43552..44598 + 1047 WP_214573806.1 class I SAM-dependent methyltransferase -
KK030_RS00215 (KK030_00215) 44659..45096 + 438 WP_214573808.1 acetyltransferase -
KK030_RS00220 (KK030_00220) 45126..45425 - 300 WP_214573810.1 helix-turn-helix transcriptional regulator Antitoxin
KK030_RS00225 (KK030_00225) 45422..45790 - 369 WP_214573812.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KK030_RS00230 (KK030_00230) 46221..46562 - 342 WP_214573814.1 SymE family type I addiction module toxin -
KK030_RS00235 (KK030_00235) 46646..46843 + 198 WP_045352823.1 toxin-antitoxin system HicB family antitoxin -
KK030_RS00240 (KK030_00240) 46856..47713 - 858 WP_045406904.1 WYL domain-containing protein -
KK030_RS00245 (KK030_00245) 47893..48063 + 171 WP_164725120.1 hypothetical protein -
KK030_RS00255 (KK030_00255) 48809..50200 + 1392 WP_214573822.1 glycoside-pentoside-hexuronide family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13999.01 Da        Isoelectric Point: 9.3784

>T268547 WP_214573812.1 NZ_CP116249:c45790-45422 [Enterobacter roggenkampii]
VDGSVRFGSVRFGKVFEQWLFEQEEGLQDKVLADLLNLQHYGPRLPRPYADTVKGSRYKHMKELRIQYAGRPVRAFFAFD
AVRQAIVLCAGDKSNDKAFYEKMIRIADAEFSLHLTSQEAAK

Download         Length: 369 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11102.05 Da        Isoelectric Point: 9.0771

>AT268547 WP_214573810.1 NZ_CP116249:c45425-45126 [Enterobacter roggenkampii]
VKTLNEVIASRSPESQQRIKEMAEEMILETGLQLLREELRISQKKVADLMGVSQPAVTQIEQRGNELKIATLKRYIEAMG
GKLCIAVELPTGKRVAFHI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References