Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3768649..3769448 Replicon chromosome
Accession NZ_CP116241
Organism Escherichia coli strain 7.1994/NIST0056

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag PH192_RS18290 Protein ID WP_033554209.1
Coordinates 3768649..3769113 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PH192_RS18295 Protein ID WP_001307405.1
Coordinates 3769113..3769448 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH192_RS18260 (3763650) 3763650..3764084 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PH192_RS18265 (3764102) 3764102..3764980 - 879 WP_033554389.1 PTS N-acetylgalactosamine transporter subunit IID -
PH192_RS18270 (3764970) 3764970..3765749 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PH192_RS18275 (3765760) 3765760..3766233 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PH192_RS18280 (3766256) 3766256..3767536 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
PH192_RS18285 (3767785) 3767785..3768594 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PH192_RS18290 (3768649) 3768649..3769113 - 465 WP_033554209.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PH192_RS18295 (3769113) 3769113..3769448 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PH192_RS18300 (3769597) 3769597..3771167 - 1571 Protein_3570 galactarate dehydratase -
PH192_RS18305 (3771542) 3771542..3772876 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PH192_RS18310 (3772892) 3772892..3773662 + 771 WP_001058226.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17811.16 Da        Isoelectric Point: 9.4947

>T268524 WP_033554209.1 NZ_CP116241:c3769113-3768649 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT268524 WP_001307405.1 NZ_CP116241:c3769448-3769113 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References