Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2978650..2979252 Replicon chromosome
Accession NZ_CP116241
Organism Escherichia coli strain 7.1994/NIST0056

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag PH192_RS14420 Protein ID WP_000897305.1
Coordinates 2978941..2979252 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PH192_RS14415 Protein ID WP_000356397.1
Coordinates 2978650..2978940 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH192_RS14390 (2974576) 2974576..2975478 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
PH192_RS14395 (2975475) 2975475..2976110 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PH192_RS14400 (2976107) 2976107..2977036 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
PH192_RS14405 (2977366) 2977366..2977608 - 243 WP_001086388.1 protein YiiF -
PH192_RS14410 (2977827) 2977827..2978045 - 219 WP_001297075.1 CopG family transcriptional regulator -
PH192_RS14415 (2978650) 2978650..2978940 - 291 WP_000356397.1 NadS family protein Antitoxin
PH192_RS14420 (2978941) 2978941..2979252 - 312 WP_000897305.1 hypothetical protein Toxin
PH192_RS14425 (2979481) 2979481..2980389 + 909 WP_001162704.1 alpha/beta hydrolase -
PH192_RS14430 (2980453) 2980453..2981394 - 942 WP_001343389.1 fatty acid biosynthesis protein FabY -
PH192_RS14435 (2981439) 2981439..2981876 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PH192_RS14440 (2981873) 2981873..2982745 - 873 WP_000920762.1 virulence factor BrkB family protein -
PH192_RS14445 (2982739) 2982739..2983338 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T268514 WP_000897305.1 NZ_CP116241:c2979252-2978941 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT268514 WP_000356397.1 NZ_CP116241:c2978940-2978650 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References