Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1594987..1595568 Replicon chromosome
Accession NZ_CP116236
Organism Gordonia polyisoprenivorans strain 135

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag PHA63_RS06920 Protein ID WP_271355208.1
Coordinates 1595287..1595568 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PHA63_RS06915 Protein ID WP_208795105.1
Coordinates 1594987..1595271 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA63_RS06890 (PHA63_06890) 1590093..1590983 + 891 Protein_1364 MazG family protein -
PHA63_RS06895 (PHA63_06895) 1591273..1592022 - 750 WP_020171998.1 GntR family transcriptional regulator -
PHA63_RS06900 (PHA63_06900) 1592125..1592550 - 426 WP_020171997.1 hypothetical protein -
PHA63_RS06905 (PHA63_06905) 1592712..1593395 - 684 WP_271355206.1 phosphonatase-like hydrolase -
PHA63_RS06910 (PHA63_06910) 1593458..1594603 - 1146 WP_271355207.1 TIGR03364 family FAD-dependent oxidoreductase -
PHA63_RS06915 (PHA63_06915) 1594987..1595271 - 285 WP_208795105.1 HigA family addiction module antitoxin Antitoxin
PHA63_RS06920 (PHA63_06920) 1595287..1595568 - 282 WP_271355208.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PHA63_RS06925 (PHA63_06925) 1595671..1596309 + 639 WP_020171992.1 GntR family transcriptional regulator -
PHA63_RS06930 (PHA63_06930) 1596306..1597562 + 1257 WP_271355209.1 MFS transporter -
PHA63_RS06935 (PHA63_06935) 1597588..1598016 + 429 WP_271355210.1 LysR family transcriptional regulator -
PHA63_RS06940 (PHA63_06940) 1597959..1598474 + 516 WP_271355751.1 LysR family substrate-binding domain-containing protein -
PHA63_RS06945 (PHA63_06945) 1598544..1599545 + 1002 WP_231386713.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-66)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10623.08 Da        Isoelectric Point: 8.0666

>T268490 WP_271355208.1 NZ_CP116236:c1595568-1595287 [Gordonia polyisoprenivorans]
VIQSFATKDTERVWARKFVPRLGPELTRVAHRKLQALDAAQRLADLASPPGNRLEPLSGDRAEQHSIRVNDQYRLCFTWT
PVGPVDMEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10688.14 Da        Isoelectric Point: 5.5882

>AT268490 WP_208795105.1 NZ_CP116236:c1595271-1594987 [Gordonia polyisoprenivorans]
MPDFEPIHPGETLAADYLPDYGLSQRKLAELIHVPPRRINEIIHGRRAITPDTSIRLGRLFGQSETFWLNMQTRYDLEIA
RATTDVSDITPLAS

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References