Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4689367..4689969 Replicon chromosome
Accession NZ_CP116197
Organism Escherichia coli strain DETEC-C31

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag PIB97_RS22350 Protein ID WP_000897305.1
Coordinates 4689658..4689969 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PIB97_RS22345 Protein ID WP_000356397.1
Coordinates 4689367..4689657 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB97_RS22320 (4685311) 4685311..4686213 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
PIB97_RS22325 (4686210) 4686210..4686845 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PIB97_RS22330 (4686842) 4686842..4687771 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
PIB97_RS22335 (4688101) 4688101..4688343 - 243 WP_001087409.1 protein YiiF -
PIB97_RS22340 (4688563) 4688563..4688781 - 219 WP_001315930.1 CopG family transcriptional regulator -
PIB97_RS22345 (4689367) 4689367..4689657 - 291 WP_000356397.1 NadS family protein Antitoxin
PIB97_RS22350 (4689658) 4689658..4689969 - 312 WP_000897305.1 hypothetical protein Toxin
PIB97_RS22355 (4690198) 4690198..4691106 + 909 WP_001162704.1 alpha/beta hydrolase -
PIB97_RS22360 (4691170) 4691170..4692111 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PIB97_RS22365 (4692156) 4692156..4692593 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PIB97_RS22370 (4692590) 4692590..4693462 - 873 WP_000920762.1 virulence factor BrkB family protein -
PIB97_RS22375 (4693456) 4693456..4694055 - 600 WP_001295269.1 glucose-1-phosphatase -
PIB97_RS22380 (4694154) 4694154..4694939 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T268432 WP_000897305.1 NZ_CP116197:c4689969-4689658 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT268432 WP_000356397.1 NZ_CP116197:c4689657-4689367 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References