Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3802842..3803383 Replicon chromosome
Accession NZ_CP116197
Organism Escherichia coli strain DETEC-C31

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag PIB97_RS18185 Protein ID WP_000615980.1
Coordinates 3803105..3803383 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q32JN2
Locus tag PIB97_RS18180 Protein ID WP_000729709.1
Coordinates 3802842..3803102 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB97_RS18165 (3798924) 3798924..3801017 + 2094 WP_021556448.1 flagellar biosynthesis protein FlhA -
PIB97_RS18170 (3801210) 3801210..3801707 - 498 WP_021556447.1 REP-associated tyrosine transposase RayT -
PIB97_RS18175 (3801883) 3801883..3802632 - 750 WP_000056850.1 C40 family peptidase -
PIB97_RS18180 (3802842) 3802842..3803102 + 261 WP_000729709.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
PIB97_RS18185 (3803105) 3803105..3803383 + 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
PIB97_RS18190 (3803539) 3803539..3804279 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
PIB97_RS18195 (3804250) 3804250..3805017 - 768 WP_000333379.1 class II glutamine amidotransferase -
PIB97_RS18200 (3805223) 3805223..3805801 - 579 WP_089628370.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3801883..3811635 9752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T268426 WP_000615980.1 NZ_CP116197:3803105-3803383 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9333.73 Da        Isoelectric Point: 5.8129

>AT268426 WP_000729709.1 NZ_CP116197:3802842-3803102 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure
AlphaFold DB A0A829FY17

References