268418

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1865165..1865667 Replicon chromosome
Accession NZ_CP116197
Organism Escherichia coli strain DETEC-C31

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag PIB97_RS08860 Protein ID WP_000767829.1
Coordinates 1865413..1865667 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag PIB97_RS08855 Protein ID WP_001259255.1
Coordinates 1865165..1865416 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB97_RS08830 (1860344) 1860344..1861411 - 1068 WP_000080085.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
PIB97_RS08835 (1861411) 1861411..1862481 - 1071 WP_000108940.1 histidinol-phosphate transaminase -
PIB97_RS08840 (1862478) 1862478..1863782 - 1305 WP_001515511.1 histidinol dehydrogenase -
PIB97_RS08845 (1863788) 1863788..1864687 - 900 WP_174402630.1 ATP phosphoribosyltransferase -
PIB97_RS08850 (1864833) 1864833..1864883 - 51 WP_001364200.1 his operon leader peptide -
PIB97_RS08855 (1865165) 1865165..1865416 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PIB97_RS08860 (1865413) 1865413..1865667 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PIB97_RS08865 (1865750) 1865750..1866574 + 825 WP_000754763.1 SDR family oxidoreductase -
PIB97_RS08870 (1866620) 1866620..1867549 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
PIB97_RS08875 (1867764) 1867764..1867826 + 63 WP_010723108.1 membrane protein YoeI -
PIB97_RS08880 (1867816) 1867816..1869174 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
PIB97_RS08885 (1869353) 1869353..1870411 + 1059 WP_023568741.1 thiosulfate utilization transporter TsuA/YeeE -
PIB97_RS08890 (1870425) 1870425..1870652 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T268418 WP_000767829.1 NZ_CP116197:1865413-1865667 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT268418 WP_001259255.1 NZ_CP116197:1865165-1865416 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References