Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 634849..635648 Replicon chromosome
Accession NZ_CP116197
Organism Escherichia coli strain DETEC-C31

Toxin (Protein)


Gene name yhaV Uniprot ID A0A161R7C1
Locus tag PIB97_RS03060 Protein ID WP_000347278.1
Coordinates 634849..635313 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PIB97_RS03065 Protein ID WP_001307405.1
Coordinates 635313..635648 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB97_RS03030 (629850) 629850..630284 - 435 WP_113419634.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PIB97_RS03035 (630302) 630302..631180 - 879 WP_021557244.1 PTS N-acetylgalactosamine transporter subunit IID -
PIB97_RS03040 (631170) 631170..631949 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PIB97_RS03045 (631960) 631960..632433 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PIB97_RS03050 (632456) 632456..633736 - 1281 WP_021557243.1 tagatose-bisphosphate aldolase subunit KbaZ -
PIB97_RS03055 (633985) 633985..634794 + 810 WP_000072174.1 aga operon transcriptional regulator AgaR -
PIB97_RS03060 (634849) 634849..635313 - 465 WP_000347278.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PIB97_RS03065 (635313) 635313..635648 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PIB97_RS03070 (635797) 635797..637368 - 1572 WP_271290923.1 galactarate dehydratase -
PIB97_RS03075 (637743) 637743..639077 + 1335 WP_174402605.1 galactarate/glucarate/glycerate transporter GarP -
PIB97_RS03080 (639093) 639093..639863 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17866.28 Da        Isoelectric Point: 9.6924

>T268414 WP_000347278.1 NZ_CP116197:c635313-634849 [Escherichia coli]
MDFPQRVNGWALYTHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT268414 WP_001307405.1 NZ_CP116197:c635648-635313 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A161R7C1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References