Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4934886..4935488 Replicon chromosome
Accession NZ_CP116194
Organism Escherichia coli strain DETEC-E1005

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag PIB63_RS24020 Protein ID WP_000897302.1
Coordinates 4934886..4935197 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PIB63_RS24025 Protein ID WP_000356397.1
Coordinates 4935198..4935488 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB63_RS23990 (4929916) 4929916..4930701 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
PIB63_RS23995 (4930800) 4930800..4931399 + 600 WP_001314324.1 glucose-1-phosphatase -
PIB63_RS24000 (4931393) 4931393..4932265 + 873 WP_000920762.1 virulence factor BrkB family protein -
PIB63_RS24005 (4932262) 4932262..4932699 + 438 WP_000560978.1 D-aminoacyl-tRNA deacylase -
PIB63_RS24010 (4932744) 4932744..4933685 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PIB63_RS24015 (4933749) 4933749..4934657 - 909 WP_001774092.1 alpha/beta hydrolase -
PIB63_RS24020 (4934886) 4934886..4935197 + 312 WP_000897302.1 hypothetical protein Toxin
PIB63_RS24025 (4935198) 4935198..4935488 + 291 WP_000356397.1 NadS family protein Antitoxin
PIB63_RS24030 (4935847) 4935847..4936125 + 279 WP_001296612.1 hypothetical protein -
PIB63_RS24035 (4936521) 4936521..4936739 + 219 WP_001314326.1 CopG family transcriptional regulator -
PIB63_RS24040 (4936955) 4936955..4937884 - 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
PIB63_RS24045 (4937881) 4937881..4938516 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PIB63_RS24050 (4938513) 4938513..4939415 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T268409 WP_000897302.1 NZ_CP116194:4934886-4935197 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT268409 WP_000356397.1 NZ_CP116194:4935198-4935488 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References