Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2839706..2840208 Replicon chromosome
Accession NZ_CP116194
Organism Escherichia coli strain DETEC-E1005

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag PIB63_RS14140 Protein ID WP_000767822.1
Coordinates 2839706..2839960 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag PIB63_RS14145 Protein ID WP_001259255.1
Coordinates 2839957..2840208 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB63_RS14120 (2836199) 2836199..2837557 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
PIB63_RS14125 (2837547) 2837547..2837609 - 63 WP_010723108.1 membrane protein YoeI -
PIB63_RS14130 (2837824) 2837824..2838753 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
PIB63_RS14135 (2838799) 2838799..2839623 - 825 WP_000754737.1 SDR family oxidoreductase -
PIB63_RS14140 (2839706) 2839706..2839960 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PIB63_RS14145 (2839957) 2839957..2840208 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PIB63_RS14150 (2840491) 2840491..2840541 + 51 WP_001364200.1 his operon leader peptide -
PIB63_RS14155 (2840687) 2840687..2841586 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
PIB63_RS14160 (2841592) 2841592..2842896 + 1305 WP_001445483.1 histidinol dehydrogenase -
PIB63_RS14165 (2842893) 2842893..2843963 + 1071 WP_001538918.1 histidinol-phosphate transaminase -
PIB63_RS14170 (2843963) 2843963..2845030 + 1068 WP_001538920.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T268403 WP_000767822.1 NZ_CP116194:c2839960-2839706 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT268403 WP_001259255.1 NZ_CP116194:c2840208-2839957 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References