268379

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3969556..3970249 Replicon chromosome
Accession NZ_CP116191
Organism Escherichia coli strain DETEC-E1070

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PIC72_RS19350 Protein ID WP_000415584.1
Coordinates 3969953..3970249 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PIC72_RS19345 Protein ID WP_000650107.1
Coordinates 3969556..3969951 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC72_RS19335 (3965420) 3965420..3967678 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
PIC72_RS19340 (3967816) 3967816..3969423 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
PIC72_RS19345 (3969556) 3969556..3969951 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PIC72_RS19350 (3969953) 3969953..3970249 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PIC72_RS19355 (3970454) 3970454..3970936 - 483 WP_000183505.1 GyrI-like domain-containing protein -
PIC72_RS19360 (3970989) 3970989..3971381 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PIC72_RS19365 (3971533) 3971533..3972192 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
PIC72_RS19370 (3972189) 3972189..3973538 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
PIC72_RS19375 (3973584) 3973584..3973916 - 333 WP_000917685.1 DUF2645 family protein -
PIC72_RS19380 (3974235) 3974235..3974816 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
PIC72_RS19385 (3974847) 3974847..3975161 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3961093..3970249 9156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T268379 WP_000415584.1 NZ_CP116191:c3970249-3969953 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT268379 WP_000650107.1 NZ_CP116191:c3969951-3969556 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References