Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2838389..2838891 Replicon chromosome
Accession NZ_CP116191
Organism Escherichia coli strain DETEC-E1070

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag PIC72_RS14135 Protein ID WP_000767822.1
Coordinates 2838389..2838643 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag PIC72_RS14140 Protein ID WP_001259255.1
Coordinates 2838640..2838891 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC72_RS14115 (2834882) 2834882..2836240 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
PIC72_RS14120 (2836230) 2836230..2836292 - 63 WP_010723108.1 membrane protein YoeI -
PIC72_RS14125 (2836507) 2836507..2837436 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
PIC72_RS14130 (2837482) 2837482..2838306 - 825 WP_000754737.1 SDR family oxidoreductase -
PIC72_RS14135 (2838389) 2838389..2838643 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PIC72_RS14140 (2838640) 2838640..2838891 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PIC72_RS14145 (2839174) 2839174..2839224 + 51 WP_001364200.1 his operon leader peptide -
PIC72_RS14150 (2839370) 2839370..2840269 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
PIC72_RS14155 (2840275) 2840275..2841579 + 1305 WP_001445483.1 histidinol dehydrogenase -
PIC72_RS14160 (2841576) 2841576..2842646 + 1071 WP_001538918.1 histidinol-phosphate transaminase -
PIC72_RS14165 (2842646) 2842646..2843713 + 1068 WP_001538920.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T268376 WP_000767822.1 NZ_CP116191:c2838643-2838389 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT268376 WP_001259255.1 NZ_CP116191:c2838891-2838640 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References