Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 691993..692251 Replicon chromosome
Accession NZ_CP116191
Organism Escherichia coli strain DETEC-E1070

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag PIC72_RS03365 Protein ID WP_000809168.1
Coordinates 691993..692145 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 692194..692251 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC72_RS03345 687238..687951 - 714 WP_001102391.1 acidic protein MsyB -
PIC72_RS03350 687977..688381 - 405 WP_000843687.1 DUF2541 family protein -
PIC72_RS03355 688753..690669 + 1917 WP_000516135.1 molecular chaperone DnaK -
PIC72_RS03360 690758..691888 + 1131 WP_001118464.1 molecular chaperone DnaJ -
PIC72_RS03365 691993..692145 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 692194..692251 + 58 - - Antitoxin
PIC72_RS03370 692760..693521 + 762 WP_001274832.1 outer membrane protein OmpK -
PIC72_RS03375 693541..695034 + 1494 WP_001774152.1 sulfatase-like hydrolase/transferase -
PIC72_RS03380 695163..696422 + 1260 WP_000494929.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T268366 WP_000809168.1 NZ_CP116191:c692145-691993 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT268366 NZ_CP116191:692194-692251 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References