Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 612146..612558 Replicon chromosome
Accession NZ_CP116191
Organism Escherichia coli strain DETEC-E1070

Toxin (Protein)


Gene name symE Uniprot ID S1NWQ7
Locus tag PIC72_RS02965 Protein ID WP_000132614.1
Coordinates 612146..612487 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 612482..612558 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC72_RS02940 (607215) 607215..608495 - 1281 WP_001338077.1 DUF445 domain-containing protein -
PIC72_RS02945 (608680) 608680..609600 + 921 WP_001513532.1 Rpn family recombination-promoting nuclease/putative transposase -
PIC72_RS02950 (609828) 609828..609908 + 81 WP_020233658.1 hypothetical protein -
PIC72_RS02955 (610006) 610006..610882 + 877 Protein_573 DUF262 domain-containing protein -
PIC72_RS02960 (610936) 610936..612099 + 1164 WP_224153787.1 DUF1524 domain-containing protein -
PIC72_RS02965 (612146) 612146..612487 - 342 WP_000132614.1 endoribonuclease SymE Toxin
- (612482) 612482..612558 + 77 NuclAT_8 - Antitoxin
- (612482) 612482..612558 + 77 NuclAT_8 - Antitoxin
- (612482) 612482..612558 + 77 NuclAT_8 - Antitoxin
- (612482) 612482..612558 + 77 NuclAT_8 - Antitoxin
- (612482) 612482..612558 + 77 NuclAT_9 - Antitoxin
- (612482) 612482..612558 + 77 NuclAT_9 - Antitoxin
- (612482) 612482..612558 + 77 NuclAT_9 - Antitoxin
- (612482) 612482..612558 + 77 NuclAT_9 - Antitoxin
PIC72_RS02970 (612708) 612708..614477 - 1770 WP_001513535.1 restriction endonuclease subunit S -
PIC72_RS02975 (614477) 614477..615946 - 1470 WP_001387312.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12266.07 Da        Isoelectric Point: 8.4982

>T268362 WP_000132614.1 NZ_CP116191:c612487-612146 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT268362 NZ_CP116191:612482-612558 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NWQ7

Antitoxin

Download structure file

References