Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4049829..4050522 Replicon chromosome
Accession NZ_CP116188
Organism Escherichia coli strain DETEC-E223

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PIC88_RS19820 Protein ID WP_000415584.1
Coordinates 4050226..4050522 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PIC88_RS19815 Protein ID WP_000650107.1
Coordinates 4049829..4050224 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC88_RS19805 (4045693) 4045693..4047951 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
PIC88_RS19810 (4048089) 4048089..4049696 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
PIC88_RS19815 (4049829) 4049829..4050224 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PIC88_RS19820 (4050226) 4050226..4050522 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PIC88_RS19825 (4050727) 4050727..4051209 - 483 WP_000183505.1 GyrI-like domain-containing protein -
PIC88_RS19830 (4051262) 4051262..4051654 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PIC88_RS19835 (4051806) 4051806..4052465 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
PIC88_RS19840 (4052462) 4052462..4053811 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
PIC88_RS19845 (4053857) 4053857..4054190 - 334 Protein_3884 DUF2645 family protein -
PIC88_RS19850 (4054509) 4054509..4055090 + 582 WP_033553897.1 NADPH:quinone oxidoreductase MdaB -
PIC88_RS19855 (4055121) 4055121..4055435 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T268348 WP_000415584.1 NZ_CP116188:c4050522-4050226 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT268348 WP_000650107.1 NZ_CP116188:c4050224-4049829 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References