Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2968133..2968635 Replicon chromosome
Accession NZ_CP116188
Organism Escherichia coli strain DETEC-E223

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7I6H4L3
Locus tag PIC88_RS14730 Protein ID WP_000767831.1
Coordinates 2968133..2968387 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag PIC88_RS14735 Protein ID WP_001259255.1
Coordinates 2968384..2968635 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC88_RS14700 (2963148) 2963148..2963375 - 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
PIC88_RS14705 (2963389) 2963389..2964447 - 1059 WP_048217810.1 thiosulfate utilization transporter TsuA/YeeE -
PIC88_RS14710 (2964626) 2964626..2965984 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
PIC88_RS14715 (2965974) 2965974..2966036 - 63 WP_010723108.1 membrane protein YoeI -
PIC88_RS14720 (2966251) 2966251..2967180 - 930 WP_048217808.1 LysR substrate-binding domain-containing protein -
PIC88_RS14725 (2967226) 2967226..2968050 - 825 WP_000754737.1 SDR family oxidoreductase -
PIC88_RS14730 (2968133) 2968133..2968387 - 255 WP_000767831.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PIC88_RS14735 (2968384) 2968384..2968635 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PIC88_RS14740 (2968919) 2968919..2968969 + 51 WP_001364200.1 his operon leader peptide -
PIC88_RS14745 (2969115) 2969115..2970014 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
PIC88_RS14750 (2970020) 2970020..2971324 + 1305 WP_001375298.1 histidinol dehydrogenase -
PIC88_RS14755 (2971321) 2971321..2972391 + 1071 WP_000108939.1 histidinol-phosphate transaminase -
PIC88_RS14760 (2972391) 2972391..2973458 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10231.67 Da        Isoelectric Point: 8.8202

>T268344 WP_000767831.1 NZ_CP116188:c2968387-2968133 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT268344 WP_001259255.1 NZ_CP116188:c2968635-2968384 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H4L3

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References