Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 898372..898913 Replicon chromosome
Accession NZ_CP116188
Organism Escherichia coli strain DETEC-E223

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag PIC88_RS04305 Protein ID WP_000615983.1
Coordinates 898372..898650 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag PIC88_RS04310 Protein ID WP_000729703.1
Coordinates 898653..898913 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC88_RS04290 (895954) 895954..896532 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
PIC88_RS04295 (896738) 896738..897505 + 768 WP_000333380.1 class II glutamine amidotransferase -
PIC88_RS04300 (897476) 897476..898216 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
PIC88_RS04305 (898372) 898372..898650 - 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
PIC88_RS04310 (898653) 898653..898913 - 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
PIC88_RS04315 (899123) 899123..899872 + 750 WP_000056849.1 C40 family peptidase -
PIC88_RS04320 (900048) 900048..900545 + 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
PIC88_RS04325 (900769) 900769..902481 - 1713 Protein_844 flagellar biosynthesis protein FlhA -
PIC88_RS04330 (902453) 902453..903238 + 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T268334 WP_000615983.1 NZ_CP116188:c898650-898372 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT268334 WP_000729703.1 NZ_CP116188:c898913-898653 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References