Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4763150..4763752 Replicon chromosome
Accession NZ_CP116181
Organism Escherichia coli strain DETEC-E480

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag PIB86_RS23280 Protein ID WP_000897302.1
Coordinates 4763441..4763752 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PIB86_RS23275 Protein ID WP_000356397.1
Coordinates 4763150..4763440 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB86_RS23245 (4758457) 4758457..4759386 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
PIB86_RS23250 (4759568) 4759568..4759810 - 243 WP_001068514.1 CopG family transcriptional regulator -
PIB86_RS23255 (4760100) 4760100..4760948 + 849 WP_001038650.1 hypothetical protein -
PIB86_RS23260 (4760973) 4760973..4761713 + 741 WP_000608806.1 hypothetical protein -
PIB86_RS23265 (4761898) 4761898..4762116 - 219 WP_001251293.1 CopG family transcriptional regulator -
PIB86_RS23270 (4762513) 4762513..4762791 - 279 WP_001296612.1 hypothetical protein -
PIB86_RS23275 (4763150) 4763150..4763440 - 291 WP_000356397.1 NadS family protein Antitoxin
PIB86_RS23280 (4763441) 4763441..4763752 - 312 WP_000897302.1 hypothetical protein Toxin
PIB86_RS23285 (4763981) 4763981..4764889 + 909 WP_001385591.1 alpha/beta hydrolase -
PIB86_RS23290 (4764953) 4764953..4765894 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PIB86_RS23295 (4765939) 4765939..4766376 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
PIB86_RS23300 (4766373) 4766373..4767245 - 873 WP_000920762.1 virulence factor BrkB family protein -
PIB86_RS23305 (4767239) 4767239..4767547 - 309 Protein_4565 HAD-IA family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4760100..4770312 10212


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T268323 WP_000897302.1 NZ_CP116181:c4763752-4763441 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT268323 WP_000356397.1 NZ_CP116181:c4763440-4763150 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References