Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1892174..1892676 Replicon chromosome
Accession NZ_CP116181
Organism Escherichia coli strain DETEC-E480

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag PIB86_RS08950 Protein ID WP_000767819.1
Coordinates 1892422..1892676 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag PIB86_RS08945 Protein ID WP_001259253.1
Coordinates 1892174..1892425 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB86_RS08920 (1887352) 1887352..1888419 - 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
PIB86_RS08925 (1888419) 1888419..1889489 - 1071 WP_000108967.1 histidinol-phosphate transaminase -
PIB86_RS08930 (1889486) 1889486..1890790 - 1305 WP_001296211.1 histidinol dehydrogenase -
PIB86_RS08935 (1890796) 1890796..1891695 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
PIB86_RS08940 (1891841) 1891841..1891891 - 51 WP_001364200.1 his operon leader peptide -
PIB86_RS08945 (1892174) 1892174..1892425 + 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PIB86_RS08950 (1892422) 1892422..1892676 + 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PIB86_RS08955 (1892759) 1892759..1893583 + 825 WP_000754737.1 SDR family oxidoreductase -
PIB86_RS08960 (1893629) 1893629..1894558 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
PIB86_RS08965 (1894773) 1894773..1894835 + 63 WP_010723108.1 membrane protein YoeI -
PIB86_RS08970 (1894825) 1894825..1896183 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -
PIB86_RS08975 (1896400) 1896400..1896858 + 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1896400..1896858 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T268309 WP_000767819.1 NZ_CP116181:1892422-1892676 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT268309 WP_001259253.1 NZ_CP116181:1892174-1892425 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References