Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4865962..4866564 Replicon chromosome
Accession NZ_CP116176
Organism Escherichia coli strain DETEC-E601

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag PIC02_RS23565 Protein ID WP_000897305.1
Coordinates 4865962..4866273 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PIC02_RS23570 Protein ID WP_000356397.1
Coordinates 4866274..4866564 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC02_RS23535 (4860992) 4860992..4861777 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
PIC02_RS23540 (4861876) 4861876..4862475 + 600 WP_001295269.1 glucose-1-phosphatase -
PIC02_RS23545 (4862469) 4862469..4863341 + 873 WP_000920762.1 virulence factor BrkB family protein -
PIC02_RS23550 (4863338) 4863338..4863775 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PIC02_RS23555 (4863820) 4863820..4864761 + 942 WP_001300148.1 fatty acid biosynthesis protein FabY -
PIC02_RS23560 (4864825) 4864825..4865733 - 909 WP_001162704.1 alpha/beta hydrolase -
PIC02_RS23565 (4865962) 4865962..4866273 + 312 WP_000897305.1 hypothetical protein Toxin
PIC02_RS23570 (4866274) 4866274..4866564 + 291 WP_000356397.1 NadS family protein Antitoxin
PIC02_RS23575 (4867169) 4867169..4867387 + 219 WP_001297075.1 CopG family transcriptional regulator -
PIC02_RS23580 (4867606) 4867606..4867848 + 243 WP_001086388.1 protein YiiF -
PIC02_RS23585 (4868178) 4868178..4869107 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
PIC02_RS23590 (4869104) 4869104..4869739 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PIC02_RS23595 (4869736) 4869736..4870638 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T268299 WP_000897305.1 NZ_CP116176:4865962-4866273 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT268299 WP_000356397.1 NZ_CP116176:4866274-4866564 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References