Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 830654..831195 Replicon chromosome
Accession NZ_CP116176
Organism Escherichia coli strain DETEC-E601

Toxin (Protein)


Gene name yafQ Uniprot ID S1FHQ9
Locus tag PIC02_RS03850 Protein ID WP_000615979.1
Coordinates 830654..830932 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag PIC02_RS03855 Protein ID WP_000729704.1
Coordinates 830935..831195 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC02_RS03835 (828236) 828236..828814 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
PIC02_RS03840 (829020) 829020..829787 + 768 WP_000333380.1 class II glutamine amidotransferase -
PIC02_RS03845 (829758) 829758..830498 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
PIC02_RS03850 (830654) 830654..830932 - 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
PIC02_RS03855 (830935) 830935..831195 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
PIC02_RS03860 (831381) 831381..832154 + 774 WP_000543899.1 C40 family peptidase -
PIC02_RS03865 (832211) 832211..832567 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
PIC02_RS03870 (832560) 832560..832838 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
PIC02_RS03875 (832943) 832943..834655 - 1713 Protein_747 flagellar biosynthesis protein FlhA -
PIC02_RS03880 (834627) 834627..835412 + 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T268285 WP_000615979.1 NZ_CP116176:c830932-830654 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT268285 WP_000729704.1 NZ_CP116176:c831195-830935 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHQ9

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References