Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4597914..4598516 Replicon chromosome
Accession NZ_CP116169
Organism Escherichia coli strain DETEC-P1056

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag PIC86_RS22170 Protein ID WP_000897305.1
Coordinates 4598205..4598516 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PIC86_RS22165 Protein ID WP_000356397.1
Coordinates 4597914..4598204 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC86_RS22140 (4593839) 4593839..4594741 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
PIC86_RS22145 (4594738) 4594738..4595373 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PIC86_RS22150 (4595370) 4595370..4596299 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
PIC86_RS22155 (4596629) 4596629..4596871 - 243 WP_001087409.1 protein YiiF -
PIC86_RS22160 (4597091) 4597091..4597309 - 219 WP_001315930.1 CopG family transcriptional regulator -
PIC86_RS22165 (4597914) 4597914..4598204 - 291 WP_000356397.1 NadS family protein Antitoxin
PIC86_RS22170 (4598205) 4598205..4598516 - 312 WP_000897305.1 hypothetical protein Toxin
PIC86_RS22175 (4598745) 4598745..4599653 + 909 WP_271292777.1 alpha/beta hydrolase -
PIC86_RS22180 (4599717) 4599717..4600658 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PIC86_RS22185 (4600703) 4600703..4601140 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PIC86_RS22190 (4601137) 4601137..4602009 - 873 WP_000920762.1 virulence factor BrkB family protein -
PIC86_RS22195 (4602003) 4602003..4602602 - 600 WP_001295269.1 glucose-1-phosphatase -
PIC86_RS22200 (4602701) 4602701..4603486 - 786 WP_098737375.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T268278 WP_000897305.1 NZ_CP116169:c4598516-4598205 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT268278 WP_000356397.1 NZ_CP116169:c4598204-4597914 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References