Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3733624..3734165 Replicon chromosome
Accession NZ_CP116159
Organism Escherichia coli strain DETEC-P351

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag PIC26_RS18040 Protein ID WP_000615983.1
Coordinates 3733887..3734165 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag PIC26_RS18035 Protein ID WP_000729703.1
Coordinates 3733624..3733884 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC26_RS18015 (3729299) 3729299..3730084 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
PIC26_RS18020 (3730056) 3730056..3731768 + 1713 Protein_3525 flagellar biosynthesis protein FlhA -
PIC26_RS18025 (3731992) 3731992..3732489 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
PIC26_RS18030 (3732665) 3732665..3733414 - 750 WP_000056849.1 C40 family peptidase -
PIC26_RS18035 (3733624) 3733624..3733884 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
PIC26_RS18040 (3733887) 3733887..3734165 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
PIC26_RS18045 (3734321) 3734321..3735061 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
PIC26_RS18050 (3735032) 3735032..3735799 - 768 WP_000333380.1 class II glutamine amidotransferase -
PIC26_RS18055 (3736005) 3736005..3736583 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3701022..3742707 41685


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T268218 WP_000615983.1 NZ_CP116159:3733887-3734165 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT268218 WP_000729703.1 NZ_CP116159:3733624-3733884 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References