Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 721213..721906 Replicon chromosome
Accession NZ_CP116159
Organism Escherichia coli strain DETEC-P351

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PIC26_RS03530 Protein ID WP_000415584.1
Coordinates 721213..721509 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PIC26_RS03535 Protein ID WP_000650107.1
Coordinates 721511..721906 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC26_RS03495 (716301) 716301..716615 - 315 WP_000958598.1 putative quinol monooxygenase -
PIC26_RS03500 (716646) 716646..717227 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
PIC26_RS03505 (717546) 717546..717878 + 333 WP_000917685.1 DUF2645 family protein -
PIC26_RS03510 (717924) 717924..719273 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
PIC26_RS03515 (719270) 719270..719929 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
PIC26_RS03520 (720081) 720081..720473 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PIC26_RS03525 (720526) 720526..721008 + 483 WP_000183505.1 GyrI-like domain-containing protein -
PIC26_RS03530 (721213) 721213..721509 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PIC26_RS03535 (721511) 721511..721906 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PIC26_RS03540 (722039) 722039..723646 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
PIC26_RS03545 (723784) 723784..726042 + 2259 WP_032329482.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T268204 WP_000415584.1 NZ_CP116159:721213-721509 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT268204 WP_000650107.1 NZ_CP116159:721511-721906 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References