Detailed information of TA system TA026819

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1054106..1054703
• Replicon: chromosome
• Accession: NC_017513
• Organism: Neisseria meningitidis G2136

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: NMBG2136_RS05725
• Protein ID: WP_002242826.1
• Coordinates: 1054425..1054703 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: NMBG2136_RS05720
• Protein ID: WP_002221020.1
• Coordinates: 1054106..1054417 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NMBG2136_RS13920	1050041..1050205	+	165	WP_002224559.1	baseplate J/gp47 family protein	-
NMBG2136_RS05705	1050205..1050816	+	612	WP_002226380.1	baseplate J/gp47 family protein	-
NMBG2136_RS05710	1050813..1051373	+	561	WP_002213590.1	YmfQ family protein	-
NMBG2136_RS05715	1051384..1053363	+	1980	WP_014580795.1	pyocin knob domain-containing protein	-
NMBG2136_RS05720	1054106..1054417	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
NMBG2136_RS05725	1054425..1054703	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NMBG2136_RS05730	1054788..1055393	+	606	WP_002219301.1	hypothetical protein	-
NMBG2136_RS05735	1055372..1055668	+	297	WP_002221017.1	hypothetical protein	-
NMBG2136_RS05740	1055665..1055874	+	210	WP_002222487.1	hypothetical protein	-
NMBG2136_RS05745	1055984..1057126	-	1143	WP_002221015.1	ABC transporter ATP-binding protein/permease	-
NMBG2136_RS05755	1057569..1058216	-	648	WP_002217218.1	DUF799 domain-containing protein	-
NMBG2136_RS05760	1058213..1058581	-	369	WP_002219297.1	DUF4810 domain-containing protein	-
NMBG2136_RS05765	1058591..1059262	-	672	WP_002217215.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1049011..1049976	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T26819 WP_002242826.1 NC_017513:c1054703-1054425 [Neisseria meningitidis G2136]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T26819 NC_017513:c1054703-1054425 [Neisseria meningitidis G2136]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT26819 WP_002221020.1 NC_017513:c1054417-1054106 [Neisseria meningitidis G2136]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT26819 NC_017513:c1054417-1054106 [Neisseria meningitidis G2136]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6