Detailed information of TA system TA026818

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4400377..4400982
• Replicon: chromosome
• Accession: NC_017506
• Organism: Marinobacter adhaerens HP15

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A4Z1BUV4
• Locus tag: HP15_RS20530
• Protein ID: WP_011786639.1
• Coordinates: 4400377..4400655 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HP15_RS20535
• Protein ID: WP_041646003.1
• Coordinates: 4400668..4400982 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP15_RS20520	4397465..4398076	-	612	WP_041646001.1	dTMP kinase	-
HP15_RS20525	4398120..4399580	+	1461	WP_014579268.1	radical SAM protein	-
HP15_RS20530	4400377..4400655	+	279	WP_011786639.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HP15_RS20535	4400668..4400982	+	315	WP_041646003.1	HigA family addiction module antidote protein	Antitoxin
HP15_RS20540	4401144..4401758	+	615	WP_014579271.1	tyrosine-type recombinase/integrase	-
HP15_RS20545	4401986..4403154	+	1169	Protein_4078	MerR family transcriptional regulator	-
HP15_RS20550	4403316..4403768	+	453	WP_041646005.1	hypothetical protein	-
HP15_RS20555	4404065..4404550	+	486	WP_041646007.1	DUF3592 domain-containing protein	-
HP15_RS20560	4404734..4405201	+	468	WP_041646010.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4376455..4408872	32417

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10765.21 Da
• Isoelectric Point: 8.5359

>T26818 WP_011786639.1 NC_017506:4400377-4400655 [Marinobacter adhaerens HP15]
MIKSFKCKHTEELVKTGKTRRFNAIQRTAERKLQQLLSAEALKDLKSPPGNRLEPLSGDREGQHSIRINDQWRLCFRWTD
EGAEDVEIVDYH

Nucleotide

• Length: 279 bp

>T26818 NC_017506:4400377-4400655 [Marinobacter adhaerens HP15]
ATGATCAAGAGCTTTAAGTGCAAGCACACAGAGGAGCTTGTAAAAACAGGTAAGACTCGGCGTTTCAATGCAATCCAGCG
AACGGCCGAGCGTAAGTTACAGCAGCTGCTAAGCGCTGAAGCTCTTAAAGATTTAAAGTCTCCGCCCGGGAATAGACTTG
AGCCGCTTTCTGGAGACAGAGAGGGGCAACACAGCATCCGGATCAATGACCAGTGGCGGTTGTGTTTCCGCTGGACAGAT
GAAGGGGCGGAAGACGTGGAGATTGTTGATTACCACTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11975.75 Da
• Isoelectric Point: 8.5038

>AT26818 WP_041646003.1 NC_017506:4400668-4400982 [Marinobacter adhaerens HP15]
MVTVGMRPIHPGEILLEDYLEPLGMSVNALSKELYVPAQRLNEIVRERRGVSADTAMRLARYFGTTEQFWLNLQTDYDLR
RAREEKADQINKLITPRKPGHHAA

Nucleotide

• Length: 315 bp

>AT26818 NC_017506:4400668-4400982 [Marinobacter adhaerens HP15]
ATGGTTACTGTAGGTATGCGCCCTATCCATCCAGGAGAGATTTTACTTGAGGATTACCTTGAGCCTCTTGGCATGAGTGT
GAATGCGCTTTCAAAAGAACTTTATGTTCCTGCACAGCGCCTGAACGAGATTGTTCGCGAGCGTCGTGGTGTGTCCGCGG
ATACGGCCATGCGTTTGGCCCGTTACTTTGGGACTACCGAGCAGTTTTGGCTCAATTTGCAGACTGACTACGATCTGCGC
CGTGCCCGTGAGGAGAAAGCCGACCAAATCAATAAACTGATTACGCCTCGTAAGCCTGGCCATCACGCTGCCTGA

Structures

Toxin

• AlphaFold DB: A0A4Z1BUV4