Detailed information of TA system TA026817

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1019557..1020154
• Replicon: chromosome
• Accession: NC_017505
• Organism: Neisseria meningitidis alpha710

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: NMBB_RS05450
• Protein ID: WP_002242826.1
• Coordinates: 1019557..1019835 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: NMBB_RS05455
• Protein ID: WP_002221020.1
• Coordinates: 1019843..1020154 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NMBB_RS05425	1016223..1016582	-	360	WP_002238090.1	hypothetical protein	-
NMBB_RS05430	1016629..1017135	-	507	WP_014575332.1	phage major tail tube protein	-
NMBB_RS05435	1017178..1018365	-	1188	WP_014575333.1	phage tail sheath subtilisin-like domain-containing protein	-
NMBB_RS14850	1018428..1018595	-	168	WP_014575334.1	hypothetical protein	-
NMBB_RS05440	1018592..1018888	-	297	WP_002242836.1	hypothetical protein	-
NMBB_RS05445	1018867..1019472	-	606	WP_014575335.1	hypothetical protein	-
NMBB_RS05450	1019557..1019835	+	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NMBB_RS05455	1019843..1020154	+	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
NMBB_RS05465	1020746..1023004	-	2259	WP_014575337.1	tail fiber protein	-
NMBB_RS14140	1023045..1023623	-	579	WP_002242773.1	phage tail protein I	-
NMBB_RS05475	1023623..1024510	-	888	WP_002238082.1	baseplate J/gp47 family protein	-
NMBB_RS05480	1024531..1024857	-	327	WP_002238081.1	GPW/gp25 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	985018..1043917	58899

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T26817 WP_002242826.1 NC_017505:1019557-1019835 [Neisseria meningitidis alpha710]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T26817 NC_017505:1019557-1019835 [Neisseria meningitidis alpha710]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT26817 WP_002221020.1 NC_017505:1019843-1020154 [Neisseria meningitidis alpha710]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT26817 NC_017505:1019843-1020154 [Neisseria meningitidis alpha710]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6