Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2859768..2860370 Replicon chromosome
Accession NZ_CP116145
Organism Escherichia coli strain DETEC-P622

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag PIB88_RS13855 Protein ID WP_000897302.1
Coordinates 2859768..2860079 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PIB88_RS13860 Protein ID WP_000356397.1
Coordinates 2860080..2860370 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB88_RS13830 (2855973) 2855973..2856281 + 309 Protein_2704 HAD-IA family hydrolase -
PIB88_RS13835 (2856275) 2856275..2857147 + 873 WP_000920762.1 virulence factor BrkB family protein -
PIB88_RS13840 (2857144) 2857144..2857581 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
PIB88_RS13845 (2857626) 2857626..2858567 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PIB88_RS13850 (2858631) 2858631..2859539 - 909 WP_001385591.1 alpha/beta hydrolase -
PIB88_RS13855 (2859768) 2859768..2860079 + 312 WP_000897302.1 hypothetical protein Toxin
PIB88_RS13860 (2860080) 2860080..2860370 + 291 WP_000356397.1 NadS family protein Antitoxin
PIB88_RS13865 (2860729) 2860729..2861007 + 279 WP_001296612.1 hypothetical protein -
PIB88_RS13870 (2861404) 2861404..2861622 + 219 WP_001251293.1 CopG family transcriptional regulator -
PIB88_RS13875 (2861807) 2861807..2862547 - 741 WP_000608806.1 hypothetical protein -
PIB88_RS13880 (2862572) 2862572..2863420 - 849 WP_001038650.1 hypothetical protein -
PIB88_RS13885 (2863710) 2863710..2863952 + 243 WP_001068514.1 CopG family transcriptional regulator -
PIB88_RS13890 (2864134) 2864134..2865063 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2854577..2863952 9375


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T268157 WP_000897302.1 NZ_CP116145:2859768-2860079 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT268157 WP_000356397.1 NZ_CP116145:2860080-2860370 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References