Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2044147..2044946 Replicon chromosome
Accession NZ_CP116145
Organism Escherichia coli strain DETEC-P622

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag PIB88_RS09855 Protein ID WP_000347251.1
Coordinates 2044482..2044946 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag PIB88_RS09850 Protein ID WP_001296435.1
Coordinates 2044147..2044482 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB88_RS09835 (2039932) 2039932..2040702 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
PIB88_RS09840 (2040718) 2040718..2042052 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
PIB88_RS09845 (2042427) 2042427..2043998 + 1572 WP_001273763.1 galactarate dehydratase -
PIB88_RS09850 (2044147) 2044147..2044482 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PIB88_RS09855 (2044482) 2044482..2044946 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PIB88_RS09860 (2045001) 2045001..2045810 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PIB88_RS09865 (2046059) 2046059..2047339 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
PIB88_RS09870 (2047362) 2047362..2047835 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PIB88_RS09875 (2047846) 2047846..2048625 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PIB88_RS09880 (2048615) 2048615..2049493 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PIB88_RS09885 (2049511) 2049511..2049945 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T268155 WP_000347251.1 NZ_CP116145:2044482-2044946 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT268155 WP_001296435.1 NZ_CP116145:2044147-2044482 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References